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Given that the kidney plays an important role in drug elimination, caution should be used when arava is administered to these patients.
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If a woman becomes pregnant while taking arava, stop treatment with arava, apprise the patient of the potential risk to a fetus, and perform an accelerated drug elimination procedure to achieve non-detectable plasma concentrations of teriflunomide, the active metabolite of leflunomide see warnings and precautions 5.
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